Abree Murch AVG Blog September 30, 2020

Revolutionizing the Production of Radioisotopes

How SHINE Medical is naturally positioned to become a leader in radioisotope production

SHINE Medical: Revolutionizing the Production of Radioisotopes

September 30, 2020 | Abree Murch

Today’s global market for diagnostic and therapeutic radioisotopes is estimated to be more than $1 billion, growing to $5+ billion by 2030. In particular, molybdenum-99 (Mo-99) is used in over 80% of nuclear medicine procedures and is critical to modern healthcare. However, 90% of global production is supplied by reactors 50+ years old — and none are in North America. 

SHINE Medical Technologies uses a patented manufacturing process to catalyze Mo-99 domestically. Their proprietary method has major economic advantages as it does not require a nuclear reactor, uses less energy, and is greener (270X less waste vs. a reactor-based facility). This naturally positions SHINE to become the world leader in the production of radioisotopes to diagnose and treat heart disease and cancer. 


Safe, Clean, and Affordable Diagnostic and Therapeutic Materials

SHINE is initially focused on producing Mo-99. Over 55K patients per day in the U.S. require Mo-99 for procedures — and incredibly, all supply is currently shipped to the U.S. from Europe, Australia, or South Africa. But Mo-99 decays at 1% per hour. Therefore, SHINE’s onshore manufacturing facility will provide it with an unrivaled cost advantage, substantially higher margins to share with distribution partners, and a multi-year head start on any U.S. competition.

At their plant in Janesville, WI — one of the most advanced private nuclear technology facilities in the world — SHINE can supply about 1/3 of global demand for Mo-99, offering U.S. customers a more secure source of a key medical isotope at a lower cost. They will also produce other isotopes, such as Lutetium 177 (Lu-177), that can be used for innovative oncology therapeutics. After a recent tour of the facility, Deputy Secretary of Energy Mark W. Menezes remarked: “DOE applauds the work being done by [SHINE], as well as the other commercial companies working with DOE, to provide U.S. patients with medical isotopes without the use of highly enriched uranium. The domestic production of Mo-99 is yet another way we will secure American leadership in the nuclear arena.”


How We’re Involved

AVG most recently participated in SHINE’s $40M Series C-3 round. Fidelity Growth Funds led the round, signaling strong conviction in SHINE’s public market potential. They were joined by new and existing investors, including a billionaire who has steadily funded SHINE with millions in multiple rounds. AVG first invested in SHINE’s Series B in 2018 and has been impressed by the company’s tremendous progress.

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